Stimuli‐Responsive Dendritic Supramolecular Vector for Tumor‐Specific Gene Delivery

To simplify the preparation of dendritic materials, host–guest molecular recognition and self-assembly are utilized to form a supramolecular gene vector (DNCVP). DNCVP is constructed from an amino dendron-conjugated naphthol, viologen containing pH-sensitive hydrazone-bond-linked PEG, CB[8] with molar ratio 1:1:1. The pH- reducing-sensitivity verified, stimuli-responsive capacity enables tumor targeting delivery ability. Owing protection surface engineering endows low cytotoxicity good biocompatibility that confirmed by MTT assay. excellent ability genes investigated in vitro transfection pEGFP, pGL3, silencing siGAPDH. In vivo studies demonstrate promoted accumulation mediated dual-responsive efficiency at site greatly improved benefiting dynamic nature noncovalent interactions. This study reveals promising vector, providing sophisticated strategy for precise therapy.